Brugia malayi Assembly and Gene Annotation

NOTE: The genome sequence and annotation for B. malayi are updated in Ensembl Metazoa approximately once per year. The data here correspond with WormBase WS260. For the latest genome and annotation, please visit WormBase ParaSite (for an Ensembl-oriented view), or WormBase.

About Brugia malayi

Brugia malayi is a gonochoristic, parasitic nematode. It is one of the causative agents of lymphatic filariasis in humans. Lymphatic filariasis, is a chronic, debilitating condition characterized by swelling of the lower limbs. The lifecycle of B. malayi involves four life stages in a mosquito host (Culex, Aedes and Anopheles), after which infectious microfilariae are transmitted to human hosts. Due to this it is restricted to South and South East Asia. B. malayi contains an Wolbachia endosymbiont, with horizontal gene transfer occurring. It is one of the tropical diseases targeted for elimination by the year 2020 by the World Health Organization.

Assembly

The B.malayi genome was first sequenced at the former TIGR institute and a first draft assembly was published in 2007 (Ghedin E, et. al.). In 2012 a new genome sequencing, assembly and curation project was conducted on the FR3 strain as a cooperative effort between WormBase and the University of Pittsburgh. This sequenced FR3 strain is available at the Filiarisis Research Reagent Center.

The gene structures are actively curated by WormBase. The annotation here corresponds with WormBase release WS260.

References

  1. Draft genome of the filarial nematode parasite Brugia malayi.
    Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D et al. 2007. Science. 317:1756-1760.
  2. The NIH-NIAID Filariasis Research Reagent Resource Center.
    Michalski ML, Griffiths KG, Williams SA, Kaplan RM, Moorhead AR. 2011. PLoS Neglected Tropical Diseases. 5:e1261.

Picture credit: Mark Blaxter (Creative Commons BY-NC-SA 3.0)

Statistics

Summary

AssemblyBmal-4.0, Dec 2015
Database version94.260
Base Pairs88,235,797
Golden Path Length88,235,797
Genebuild byWormBase
Genebuild methodImport
Data sourceWormBase

Gene counts

Coding genes11,010
Non coding genes455
Small non coding genes455
Pseudogenes306
Gene transcripts14,793

About this species