Brugia malayi Assembly and Gene Annotation
About Brugia malayi
Brugia malayi is a gonochoristic, parasitic nematode. It is one of the causative agents of lymphatic filariasis in humans. Lymphatic filariasis, is a chronic, debilitating condition characterized by swelling of the lower limbs. The lifecycle of B. malayi involves four life stages in a mosquito host (Culex, Aedes and Anopheles), after which infectious microfilariae are transmitted to human hosts. Due to this it is restricted to South and South East Asia. B. malayi contains an Wolbachia endosymbiont, with horizontal gene transfer occurring. It is one of the tropical diseases targeted for elimination by the year 2020 by the World Health Organization.
- B. malayi data at WormBase
- B. malayi data at WormBase ParaSite
- Filariasis Research Reagents Center
- Brugia malayi TRS strain Wolbachia Genome at Ensembl Genomes
- WHO Global Program to Eliminate Lymphatic Filariasis
The B.malayi genome was first sequenced at the former TIGR institute and a first draft assembly was published in 2007 (Ghedin E, et. al.). In 2012 a new genome sequencing, assembly and curation project was conducted on the FR3 strain as a cooperative effort between WormBase and the University of Pittsburgh. This sequenced FR3 strain is available at the Filiarisis Research Reagent Center.
- Draft genome of the filarial nematode parasite Brugia malayi.
Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D et al. 2007. Science. 317:1756-1760.
- The NIH-NIAID Filariasis Research Reagent Resource Center.
Michalski ML, Griffiths KG, Williams SA, Kaplan RM, Moorhead AR. 2011. PLoS Neglected Tropical Diseases. 5:e1261.
Picture credit: Mark Blaxter (Creative Commons BY-NC-SA 3.0)
|Assembly||Bmal-4.0, Dec 2015|
|Golden Path Length||88,235,797|
|Non coding genes||455|
|Small non coding genes||455|