Brugia malayi (Nematode, FR3) Assembly and Gene Annotation

NOTE: The genome sequence and annotation for B. malayi are updated in Ensembl Metazoa infrequently. The data here correspond with WormBase WS279. For the latest genome and annotation, please visit WormBase ParaSite or WormBase.

About Brugia malayi

Brugia malayi is a gonochoristic, parasitic nematode. It is one of the causative agents of lymphatic filariasis in humans. Lymphatic filariasis, is a chronic, debilitating condition characterized by swelling of the lower limbs. The lifecycle of B. malayi involves four life stages in a mosquito host (Culex, Aedes and Anopheles), after which infectious microfilariae are transmitted to human hosts. Due to this it is restricted to South and South East Asia. B. malayi contains an Wolbachia endosymbiont, with horizontal gene transfer occurring. It is one of the tropical diseases targeted for elimination by the year 2020 by the World Health Organization.

• B. malayi data at WormBase.
• B. malayi data at WormBase ParaSite.
• Filariasis Research Reagents Center.
• Brugia malayi TRS strain Wolbachia Genome at Ensembl Genomes.
• Lymphatic Filariasis, World Health Organization.

Picture credit: Public domain via Wikimedia Commons (Image source)

Assembly

The B.malayi genome was first sequenced at the former TIGR institute and a first draft assembly was published in 2007 (Ghedin E, et. al.). In 2012 a new genome sequencing, assembly and curation project was conducted on the FR3 strain as a cooperative effort between WormBase and the University of Pittsburgh as described by Tracey et al. 2020. This sequenced FR3 strain is available at the Filiarisis Research Reagent Center.

Annotation

The gene structures are actively curated by WormBase. The annotation here corresponds with WormBase release WS279.

References

1. Nearly Complete Genome Sequence of Brugia malayi Strain FR3..
   Tracey A, Foster JM, Paulini M, et al. Nearly Complete Genome Sequence of Brugia malayi Strain FR3. Microbiology Resource Announcements. 2020 Jun;9(24).
2. Draft genome of the filarial nematode parasite Brugia malayi.
   Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D et al. 2007. Science. 317:1756-1760.
3. The NIH-NIAID Filariasis Research Reagent Resource Center.
   Michalski ML, Griffiths KG, Williams SA, Kaplan RM, Moorhead AR. 2011. PLoS Neglected Tropical Diseases. 5:e1261.

Picture credit: Mark Blaxter (Creative Commons BY-NC-SA 3.0)

Links

• B. malayi data at WormBase.
• B. malayi data at WormBase ParaSite.