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DB built by FlyBase

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Gene: Top1 FBgn0004924

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Description

Topoisomerase 1

Gene Synonyms

Location

Primary_assembly X: 15,319,479-15,328,029 forward strand.

BDGP6.46:AE014298.5

About this gene

This gene has 5 transcripts (splice variants) and 59 orthologues.

Transcripts

Show transcript tableHide transcript table

Name	Transcript ID	bp	Protein	Translation ID	Biotype	UniProt	RefSeq	Flags
Top1-RC	FBtr0100294	5325	974aa	FBpp0099689	Gene/transcipt that contains an open reading frame (ORF).Protein coding	P30189 Q494M1	-	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, APPRIS P2: Where the APPRIS core modules are unable to choose a clear principal variant (approximately 25% of human protein coding genes), the database chooses two or more of the CDS variants as "candidates" to be the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P2,
Top1-RD	FBtr0308699	4600	970aa	FBpp0300905	Gene/transcipt that contains an open reading frame (ORF).Protein coding	M9NDX3 Q1WWG8	-	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,
Top1-RA	FBtr0074005	4265	974aa	FBpp0073822	Gene/transcipt that contains an open reading frame (ORF).Protein coding	Q494M1	-	APPRIS P2: Where the APPRIS core modules are unable to choose a clear principal variant (approximately 25% of human protein coding genes), the database chooses two or more of the CDS variants as "candidates" to be the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P2,
Top1-RE	FBtr0340434	3942	593aa	FBpp0309379	Gene/transcipt that contains an open reading frame (ORF).Protein coding	X2JKD2	-	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,
Top1-RB	FBtr0074006	2378	581aa	FBpp0073823	Gene/transcipt that contains an open reading frame (ORF).Protein coding	C6TPA7 Q8IR39	-	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,

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Summary

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