Necator americanus (New World hookworm, N. amaericanus Hunan isolate) Assembly and Gene Annotation

NOTE: The genome sequence and annotation for this nematode are updated in Ensembl Metazoa infrequently. For the latest genome and annotation, please visit WormBase ParaSite.

About Necator americanus

The hookworm Necator americanus is a parasitic nematode commonly known as the New World hookworm. Hookworms infect around 700 million people globally, causing a disease burden of 1.5-22.1 million disability-adjusted life years. Around 85% of all hookworm infections in humans are coming from this species causing Necatoriasis, a disease characterised by impairment of development in children, anaemia and malnutrition in pregnant women.

Unembryonated Necator americanus eggs are passed in the stool and under favourable conditions the larvae hatch in soil. After maturating in the soil, the larvae becomes infective and in contact with the human host, typically bare feet, penetrate the skin and enter the bloodstream. After being carried to the lungs, they make it up to the bronchial tree and are swallowed. Larvae then reach the jejunum of the small intestine, where they mature into adults.

• Necator Americanus data at WormBase ParaSite.
• Information on necatoriasis by CDC.

Picture credit: Jasper Lawrence Creative Commons Attribution 4.0 via Wikimedia Commons (Image source)

Assembly

The N. americanus genome was sequenced by the Mitreva laboratory at the Genome Institute of Washington University, as described by Tang et al (2014).

Annotation

The gene predictions were made by the Mitreva laboratory at the Genome Institute of Washington University, as described by Tang et al (2014). The version represented here is consistent with the INSDC records.

1. Genome of the human hookworm Necator americanus.
   PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RW, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. 2014. Nat Genet, 2014;46(3):261-269

Picture credit: File:Necator_americanus_(YPM_IZ_095221).jpeg provided by Yale Peabody Museum of Natural History. Photographer: Daniel J. Drew. This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.

Links

Necator Americanus data at WormBase ParaSite.