About Schistosoma mansoni

Schistosoma mansoni is one of a genus of trematodes that are commonly called blood-flukes, and is a significant parasite of humans and a major agent of the disease schistosomiasis. S. mansoni goes through several asexual reproductive stages in an intermediate host, a freshwater snail, from which many thousands of motile larval forms (cercaria) emerge. The cercaria can quickly penetrate human skin, and within a few days enter the circulatory system, where they feed on blood. The adult stage of S. mansoni has two sexes, in contrast to the hermaphroditic nature of most trematodes, and if a larva encounters a member of the opposite sex it develops into a sexually mature adult and the two larvae form a monogamous pairing. Females can lay hundreds of eggs per day, and these migrate to the intestines and then enter the environment in faeces, ready to hatch and infect snail hosts. In (intestinal) schistosomiasis, an immune response is initiated when eggs become trapped in the intestinal wall, or other organs such as the liver, and it is this severe immune response that underlies the disease pathology.

Picture credit (public domain): Uniformed Services University of the Health Sciences 2006

Taxonomy ID 6183

Data source SchistoDB

More information and statistics

Gene annotation

What can I find? Protein-coding and non-coding genes, splice variants, cDNA and protein sequences, non-coding RNAs.

More about this genebuild

Download genes, cDNAs, ncRNA, proteins - FASTA - GFF3

Update your old Ensembl IDs

Comparative genomics

What can I find? Homologues, gene trees, and whole genome alignments across multiple species.

More about comparative analyses

Phylogenetic overview of gene families

Download alignments (EMF)

Variation

This species currently has no variation database. However you can process your own variants using the Variant Effect Predictor:

Variant Effect Predictor

Links

  • GeneDB, part of the Sanger Institute's Pathogen genomics project.
  • SchistoDB, a Schistosoma mansoni genome resource [3].

About this species