Necator americanus (PRJNA72135) Assembly and Gene Annotation
NOTE: The genome sequence and annotation for this nematode are updated in Ensembl Metazoa infrequently. For the latest genome and annotation, please visit WormBase ParaSite.
About Necator americanus
The hookworm Necator americanus is a parasitic nematode commonly known as the New World hookworm. Hookworms infect around 700 million people globally, causing a disease burden of 1.5-22.1 million disability-adjusted life years. Around 85% of all hookworm infections in humans are coming from this species causing Necatoriasis, a disease characterised by impairment of development in children, anaemia and malnutrition in pregnant women.
Unembryonated Necator americanus eggs are passed in the stool and under favourable conditions the larvae hatch in soil. After maturating in the soil, the larvae becomes infective and in contact with the human host, typically bare feet, penetrate the skin and enter the bloodstream. After being carried to the lungs, they make it up to the bronchial tree and are swallowed. Larvae then reach the jejunum of the small intestine, where they mature into adults.
The N. americanus genome was sequenced by the Mitreva laboratory at the Genome Institute of Washington University, as described by Tang et al (2014).
The gene predictions were made by the Mitreva laboratory at the Genome Institute of Washington University, as described by Tang et al (2014). The version represented here is consistent with the INSDC records.
- Genome of the human hookworm Necator americanus.
PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RW, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. 2014. Nat Genet, 2014;46(3):261-269
Picture credit: File:Necator_americanus_(YPM_IZ_095221).jpeg provided by Yale Peabody Museum of Natural History. Photographer: Daniel J. Drew. This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
|Assembly||N_americanus_v1, INSDC Assembly GCA_000507365.1,|
|Golden Path Length||244,075,060|
|Genebuild by||McDonnell Genome Institute|
|Data source||McDonnell Genome Institute|